REPO-TRIAL is a €5.5M EU funded platform for developing a computerized (in silico) approach to optimise the efficacy and precision of drug repurposing trials. It aims to improve the efficacy and precision of drug repurposing by redefining diseases entirely mechanistically, as opposed to merely descriptive definitions by symptom or organ. To reach this goal, REPO-TRIAL will exploit the existing wealth of medical big data and use advanced algorithms and cutting edge in silico modelling.